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In the fitness community and on various online forums, it is touted as a muscle-boosting supplement that elicits weight loss and promotes muscle building and repair. In this article, we briefly review studies that report the anti-ageing effects of creatine in humans and animals, and then we present the main evidence that supports this idea. Creatine as a Supplement In humans, creatine can either supplement to the normal levels that one experiences during aerobic exercise or supplemental through creatine supplements, but there is increasing evidence to suggest that the creatine found commercially is not an adequate source of creatine for human consumption and does not enhance athletic performance. In animals, creatine appears to be used to enhance muscle growth in both lean muscle and fat mass. Creatine is not generally effective in helping humans to build muscle mass due to its low bioavailability. However it has been noted that creatine supplementation in otherwise healthy individuals can confer skeletal muscle preservation, particularly in skeletal muscle tissue with low levels of creatine transporter protein expression. There have also been reports that creatine can be used to enhance skeletal muscle repair, muscle growth, and muscle strength, although these studies were not designed to test these claims. In the animal, creatine appears to enhance creatine transporter protein expression, but it is not known if it is also used in humans to enhance muscle function and growth. Animal Studies and Humans Creatine is a fat-soluble compound that is metabolized by the kidneys to creatine monohydrate. The kidneys use the monohydrate as a phosphate-based fuel in a process called transamination to generate phosphocreatine; a molecule that can be used by muscle cells for oxidative and muscle-specific functions. The two major sources of creatine for humans are sports drinks that are formulated for muscular endurance exercise. In humans, creatine monohydrate is most commonly consumed via dietary supplements, most likely via creatine monohydrate phosphate and creatine citrate (and possibly also creatine citrate phosphate) and creatine adenine dinucleotide (CCD). Supplementation with creatine does not seem to significantly alter muscle size or strength in humans who normally ingest creatine monohydrate. It has been noted that the amount of creatine in the body was determined in the range of 10-20g daily for 10 days during research by the Department of Exercise and Sports Medicine at the University of Glasgow. Supplementation of creatine in humans has been not well evaluated in terms of strength and power in either the lean or muscular states. Supplementations from creatine mon Similar articles: