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In some embodiments, agents treating pharmacotherapy induced hypogonadal and/or osteopenic and/or sarcopenic states include but are not limited to opioids, narcotics, opiates, opioids, methadone, kadian, D2 dopamine receptor antagonist, zotepine, haloperidol, amisulpride, risperidone, anti-epileptic agent, valproic acid, carbamazepine, oxcarbamazepine, chemotherapeutic agent, methotrexate, cyclophosphamide, ifosfamide, adriamycin, doxorubicin, glucocorticoids, cyclosporine, L-thyroxine, SERMs, Al, fulvestrant, gonadotropin-releasing hormone agent, androgen depravation agent, prolactinemia-inducing agent, serotonergic antidepressant, selective serotonin reuptake inhibitor, monoamine oxidase inhibitor, tricyclic antidepressant, antihypertensive agents, methyldopa, reserpine, clonidine, verapamil, antidopaminergic agent, anti-emetic agent, metoclopramide, H2 receptor antagonist, cimetidine, ranitidine, estrogen, or amphetamine, stenabolic sarm side effects. In some embodiments, vitamins include but are not limited to vitamin D, vitamin E, vitamin K, vitamin B, vitamin C, or a combination thereof. A is a group selected from: R2 t R3 r N RR4 1, taking estrogen with mirena. R5 R8 wherein R2, R3, R4, R5, R6 are independently is H, halogen, NO2, CN, NHCOR9, N(COR9)2, CORjo, OR,I, OSO2R12, S02RI3, NHSO2RI2, SR14, an imide ring, alkyl or substituted alkyl with at least one substituent of halogen, CN, NH2, OH, alkoxy; or R2 and R3, R3 and R4, R4 and R5, or R5 and R6 form, together with any of the ring atom(s) to which they are attached, a condensed 5 to 7 membered aliphatic or aromatic carbocyclic ring or a condensed 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatom(s) selected from N, 0, S; or represented by structures A, B or C: NH O B / NH C R7 and R8 are independently H, halogen, alkyl or alkenyl 23. 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